RE: Depo Medrol vs Prednisone page 2

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Phil P:
[nq:1]Here are the questions: have any of you had cats who needed long-term steroids? Did any of them develop side effects from either quarterly Depo Medrol shots or long-term use of oral prednisone? If so, what happened?[/nq]
Not an easy question Cats usually require high dosages - higher than dogs, at least - to get the same effect, but they also seem to develop less adverse effects than dogs. Usually, but I can't say always - its better to give a cat larger doses less frequently than smaller doses more frequently - and taper the dose to the smallest amount that will produce the effect you want. Steroids have an effect on almost every cell in the body - some cells can handle the effects better than others - so to my mind, the least dose as possible that will prpduce the desired effect the better.
I've had a few cats develop PD/PU (polydipsia/polyuria) from long-term prednisone therapy that resolved almost completely by switching to methylprednisolone (less mineralocorticoid effects than prednisone). A few also developed polyphagia (increased appetite) - nothing serious - I just had to adjust their feeding patterns - same kcal/day just smaller and more frequent meals - kept them satiated without feeling hungry all day. Most of them did fine on regular b.i.d. feeding without any changes.
Your greatest fear is probably diabetes. Steroids, especially daily prednisone, causes glycogen to be converted back into glucose and then released back into the bloodstream. This isn't true diabetes and not that common with alternate day dosing and even much less common with monthly and even less common with alternate month depo and almost also resolves with discontinuance of steroid therapy.
Most of the adverse effects you read about steroid therapy are caused by long term, every day dosing. Of course, as with any therapy, a careful assessment of the risk to benefit ratio must be made. In your cat's case, and in those of millions of other cats, the benefits of steroid therapy far outweigh the risks and have literally made the difference between a happy life and a miserable life as the difference between life and death for many cats.
Best of luck.
Phil
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Gail:
My cat Shadow sufferes from Inflammatory bowel disease. She has been on Prednisone for over 8 years now with no bad side effects. The only side effects I've seen are increased appetite on the Prednisone. She is now 16 and 1/2.
Gail
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Yngver:
[nq:1]He also told me that oral Prednisone will be fine for her asthma but will not do as good a ... happened? Any opinions on what I ought to do are welcome. I appreciate your input and thank you in advance.[/nq]
The treatment of choice for asthma is now becoming inhalable medication such as Flovent. Inhaled steroids go directly to the lungs and do not have the negative side effects of injectable or oral prednisone. It seems to me you might want to consider Flovent for the asthma and something else for the linear granuloma. That way you will avoid the serious risks associated with long-term use of oral prednisone.
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-L.:
Yes. She doesn't have EGC very bad - but has had it since 8 weeks old - probably was born with it. She breaks out about 1-2 times per year. Now that she's older, she has broken out more often.

-L.
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Ginger-lyn Summer:
[nq:1]I need to make a choice about whether to continue Cheeks (4-year-old shelter rescue, female, spayed, and with beautiful intact ... happened? Any opinions on what I ought to do are welcome. I appreciate your input and thank you in advance.[/nq]
I have two cats with asthma and one with EGC. Trill, with EGC, was only diagnosed last year and has only had a few shots, but it certainly hasn't seemed to be a problem for him.
Internet, with asthma, has been on 1/2 tablet Prednisolone every other day for about two years, with no noticeable problems or side effects to date.
Sabra, with more severe asthma, has been on one tablet of Prednisone every third day (dosages have changed over time) for maybe 6-7 years? I have seen no obvious problems with him, either. He also gets Albuterol occasionally as well. Attacks have been rare in the past year since going to this dosage schedule with the Albuterol.

I do worry about side effects, but so far, I have not seen any problems in my guys.
Best of luck to you and your kitty!
Ginger-lyn
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Cheryl:
on 03 Feb 2004:

I took note of the vitamins Shamrock takes and they are EFAVites by Allerderm. I also forgot to mention that Shadow is on Prednisone daily (5mg) for his IBD for ~18 months, and while I've tried to lower the dose without success, his only real side effect from it so far is an increase in appetite.

Cheryl
Trapped like rats. In a chia-pet.
MIB II
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Wendy:
on 03 Feb 2004:

I took note of the vitamins Shamrock takes and they are EFAVites by Allerderm. I also forgot to mention that Shadow is on Prednisone daily (5mg) for his IBD for ~18 months, and while I've tried to lower the dose without success, his only real side effect from it so far is an increase in appetite.

Cheryl
Can make them drink more too?
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Laura R.:
circa Wed, 4 Feb 2004 07:53:06 -0500, in rec.pets.cats.health+behav, Wendy (Email Removed) said,
[nq:1]I took note of the vitamins Shamrock takes and they are EFAVites by Allerderm. I also forgot to mention that ... real side effect from it so far is an increase in appetite. Cheryl Can make them drink more too?[/nq]
Prednisone didn't make Alex drink more, but it definitely increased his appetite. Given that he had lymphoma, this was a very, very good thing.
Laura

I am Dyslexia of Borg,
Your ass will be laminated.
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Mary:
[nq:1]I read up on this and found the following article which is why I asked about antihistamines:[/nq]
http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&PID=2544
Cheryl, forgive me if I take this one step at a time but the clinical language is
difficult for me. In the first part of the article, if I get it, they are saying that
both food and arthropod (bugs, fleas, roaches, any chitin-exoskeletoned creature) allergies have been linked to Feline Eosinophilic Skin Disease (let's call it FESD), and that there appears to be a hereditary component since many cats who are related get it.

Before I go further, may I ask what foods, if any, they have isolated as possibly contributing to this problem? Thank you, I will read more tonight after work and try to read and digest all of the comments. This is important to me so I appreciate everyone's input and want to understand it fully.
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