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My cat Brutus is acting weird. We just got back from a 2 day vacation and we expected him to run over and be happy to see us...but he didnt. He hobbled over and just sat down. He doesnt move hardly at all, he won't jump, he can't get up the stairs on his own and he will not drink water or eat very much. Im very concerned. My best friend Poochie, my dog, died last year of intestinal cancer so im very worried about my cat. Please do you guys have any information?
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Hey brookster,
I'm afraid we won't be able to help you since there's too little information about your cat. The symptoms you described (a loss of appetite, apathy, and a loss of activity) look very much like your kitty is ill, but they can be signs of really various health issues. I guess there are also problems with him defecating and peeing, aren't there?

Only a vet can tell how serious it is, so (even though I hate writing "take him to a vet!") I'd agree with anon: take him to a vet as soon as possible, his behaviour is clearly showing that something is wrong.
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Do AS I WOULD DO... STRAIGHT TO THE VET.. NO SECOND THOUGHTS. IF YOU LOVE YOUR CAT AS I LOVE MINE. THEN DO IT PLEASE.

ITS OBVIOUS HE ISNT WELL.

SIGH
 Ruslana's reply was promoted to an answer.